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Abs to Transcription Factors, Homeobox (HOX)
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Anti -NKX3.1 (Homeobox Protein Nkx-3.1, Homeobox Protein NK-3 Homolog A, NKX3-1, NKX3A)
Anti -NKX3.1 (Homeobox Protein Nkx-3.1, Homeobox Protein NK-3 Homolog A, NKX3-1, NKX3A)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
E B IH FC |
|
| NKX3.1, a 234aa tumor suppressor protein, is a novel member of NK Class of Homeodomain proteins. It is a human homolog of NK3 (Drosophila) and Nkx3.1 (Mouse) and consists of a highly conserved DNA-binding Homeodomain. It plays a vital role in prostrate epithelial cell development, differentiation and carcinogenesis. Its expression is androgen-regulated and has growth suppression and differentiation effects in prostrate epithelial cells. It acts as a transcriptional repressor of PSA promoter by interacting with Prostrate-derived Ets factor. Its role has also been implicated in growth of testicular epithelial cells. It is specifically expressed in prostrate and testis & loss of expression has been detected in prostrate carcinomas, prostatic intraepithelial neoplasia and testicular cancers of germ cell origin. | | | Catalog # | N2850-30P | | Applications | Suitable for use in Flow Cytometry, ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1:200-1:400 | | Western Blot: 1:500-1:2000 | | Immunohistochemistry (Formalin fixed paraffin embedded): 1:200 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | 4H4 | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid, 0.03% sodium azide. | | Purity | Ascites | | Immunogen | Recombinant corresponding to human NKX3-1. | | Specificity | Recognizes human NKX3-1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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