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You are here:Home » Antibodies » Abs to Transcription Factors, Homeobox (HOX) » Anti -NKX3.1 (Homeobox Protein Nkx-3.1, Homeobox Protein NK-3 Homolog A, NKX3-1, NKX3A)

Anti -NKX3.1 (Homeobox Protein Nkx-3.1, Homeobox Protein NK-3 Homolog A, NKX3-1, NKX3A)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B IH FC
NKX3.1, a 234aa tumor suppressor protein, is a novel member of NK Class of Homeodomain proteins. It is a human homolog of NK3 (Drosophila) and Nkx3.1 (Mouse) and consists of a highly conserved DNA-binding Homeodomain. It plays a vital role in prostrate epithelial cell development, differentiation and carcinogenesis. Its expression is androgen-regulated and has growth suppression and differentiation effects in prostrate epithelial cells. It acts as a transcriptional repressor of PSA promoter by interacting with Prostrate-derived Ets factor. Its role has also been implicated in growth of testicular epithelial cells. It is specifically expressed in prostrate and testis & loss of expression has been detected in prostrate carcinomas, prostatic intraepithelial neoplasia and testicular cancers of germ cell origin.
Catalog #N2850-30P
ApplicationsSuitable for use in Flow Cytometry, ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:200-1:400
Western Blot: 1:500-1:2000
Immunohistochemistry (Formalin fixed paraffin embedded): 1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No4H4
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.03% sodium azide.
PurityAscites
ImmunogenRecombinant corresponding to human NKX3-1.
SpecificityRecognizes human NKX3-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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