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You are here:Home » Antibodies » Abs to Ion Channel » Anti -NMDA 1 Receptor

Anti -NMDA 1 Receptor

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
N-methyl-D-Aspartate (NMDA) type receptors are glutamate-activated calcium channels that play central roles in brain function and disease. Activation of NMDA receptors leads to elevations in synaptic calcium levels, initiating a series of calcium dependent signaling events including activation of nitric oxide synthase and stimulation of calcium/calmodulin dependent protein kinase, and MAP kinase cascades. Through these signal transduction pathways, NMDA receptors mediate both synaptic plasticity and learning and memory. NMDA receptors are composed of multiple subunits. The subunits are thought to co-assemble in different combinations to form functionally distinct NMDA receptors. All receptors contain an NR1 subunit and various numbers of NR2 subunits. NR2b is the major subunit expressed in adult forebrain. NR2 is also a major component of the postsynaptic density in hippocampus and cerebral cortex. The NR1 subunit is encoded by a single gene, which undergoes extensive alternative splicing to generate eight different splice forms. The NR2 subunit class consists of four genes encoding the subunits NR2A-NR2D. In addition to mediating diverse aspects of synaptic physiology, NMDA receptors also play a major role in neurodegenerative diseases. Overactivity of NMDA receptors is implicated in numerous neurodegenerative processes including stroke, Alzheimer’s disease, Huntington’s chorea, and amyotrophic lateral sclerosis.
Catalog #N2904-34
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsELISA: 0.1-1ug/ml
Western Blot: 1-5ug/ml
Immunohistochemistry (Frozen): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No3G211
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenFusion protein containing sequence from the intracellular loop between transmembrane regions III and IV of NMDAR1.
SpecificityRecognizes human NMDAR1 at ~103kD. Does not crossreact with other NMDA receptor proteins. Species Crossreactivity: mouse, rat and monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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