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You are here:Home » Antibodies » Abs to Enzymes, Carboxypeptidase » Anti -NNA1 (Cytosolic Carboxypeptidase 1, ATP/GTP-binding Protein 1, Nervous System Nuclear Protein Induced by Axotomy Protein 1 Homolog, CCP1, KIAA1035, AGTPBP1)

Anti -NNA1 (Cytosolic Carboxypeptidase 1, ATP/GTP-binding Protein 1, Nervous System
Nuclear Protein Induced by Axotomy Protein 1 Homolog, CCP1, KIAA1035, AGTPBP1)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Nervous system nuclear protein induced by axotomy 1 (Nna1, AGTPBP1 or cytosolic carboxypeptidase-1) is related to zinc carboxypeptidases and contains an ATP/GTP binding motif, a basic and a bipartite nuclear localization signal. Nna1 expression is rapidly induced in motor neurons following axotomy and down-regulated following reinnervation, which is consistent with abundant Nna1 expression in differentiating neurons and the absence of Nna1 in CNS proliferative zones. Furthermore, Purkinje cell degeneration is characterized by adult onset neurodegeneration resulting from Nna1 gene mutations, implicating Nna1 in mechanisms common to degeneration and regeneration.
Catalog #N2920-05
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:8000
Western Blot: 1-3ug/ml, lysates of cell line HeLa observed on ~150kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-TSPLEYNLPS, from human AGTPBP1, at the internal region of the protein (NP_056054.2).
SpecificityRecognizes human AGTPBP1. Species sequence homology: Bovine, canine, mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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