You are here:Home
»
Antibodies
»
Abs to Apoptosis, Caspase
»
Anti -NOD2 (Nucleotide-binding Oligomerization Domain-containing Protein 2, Caspase Recruitment Domain-containing Protein 15, Inflammatory Bowel Disease Protein 1, CARD15, IBD1)
Anti -NOD2 (Nucleotide-binding Oligomerization Domain-containing Protein 2, Caspase
Recruitment Domain-containing Protein 15, Inflammatory Bowel Disease Protein 1, CARD15,
IBD1)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Affinity Purified |
B IH |
|
| Apaf-1 and NOD1 are members of a new family, which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2. NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-kB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn's disease that is a main type of chronic inflammatory bowel disease. | | | Catalog # | N3006-02C | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1,k | | Clone No | 26mNOD2 | | Host | Rat | | Source | Mouse | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Mouse NOD2 | | Specificity | Recognizes mouse NOD2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
