Anti -NONO, CT (Non-POU Domain-containing Octamer-binding Protein, NonO Protein, 54kD
Nuclear RNA- and DNA-binding Protein, 55kD Nuclear Protein, DNA-binding p52/p100 Complex,
52kD Subunit, NMT55, p54(nrb), p54nrb, NRB54)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B IH |
|
| Non-POU-domain-containing octamer binding protein (NONO) is a member of the DBHS (drosophila behavior, human splicing) domain-containing family and is an RNA- and DNA- binding protein. NONO and other DBHS domain-containing proteins are multifunctional and are reported to be involved in transcriptional regulation, mRNA processing, and DNA non-homologous end joining (NHEJ). NONO functions as a coregulator of the androgen receptor (AR) and also regulates cAMP transcriptional activity by interacting with gene promoter elements. NONO is also involved in pre-mRNA splicing through an interaction with U5 snRNA and can stimulate DNA nonhomologous end joining (NHEJ) through the interaction with ku70/G22p and ku80/XRCC5 dimers. Alternate names for NONO include 54kD nuclear RNA- and DNA-binding protein, p54 (nrb), 55kD nuclear protein, NMT55, DNA-binding p52/p100 complex, NRB54, P54, and P54NRB. | | | Catalog # | N3520-02A | | Applications | Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 0.1-0.3ug/ml | | ELISA: 1:16,000 | | Immunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide C-NRAAPGAEFAPNK from the C-terminus of human NONO. | | Specificity | Recognizes human NONO. Species sequence homology: canine, rat and mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -NONO, CT (Non-POU Domain-containing Octamer-binding Protein, NonO Protein, 54kD Nuclear RNA- and DNA-binding Protein, 55kD Nuclear Protein, DNA-binding p52/p100 Complex, 52kD Subunit, NMT55, p54(nrb), p54nrb, NRB54) |
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