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You are here:Home » Antibodies » Abs to RNA Processing » Anti -NONO, CT (Non-POU Domain-containing Octamer-binding Protein, NonO Protein, 54kD Nuclear RNA- and DNA-binding Protein, 55kD Nuclear Protein, DNA-binding p52/p100 Complex, 52kD Subunit, NMT55, p54(nrb), p54nrb, NRB54)

Anti -NONO, CT (Non-POU Domain-containing Octamer-binding Protein, NonO Protein, 54kD
Nuclear RNA- and DNA-binding Protein, 55kD Nuclear Protein, DNA-binding p52/p100 Complex,
52kD Subunit, NMT55, p54(nrb), p54nrb, NRB54)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IH
Non-POU-domain-containing octamer binding protein (NONO) is a member of the DBHS (drosophila behavior, human splicing) domain-containing family and is an RNA- and DNA- binding protein. NONO and other DBHS domain-containing proteins are multifunctional and are reported to be involved in transcriptional regulation, mRNA processing, and DNA non-homologous end joining (NHEJ). NONO functions as a coregulator of the androgen receptor (AR) and also regulates cAMP transcriptional activity by interacting with gene promoter elements. NONO is also involved in pre-mRNA splicing through an interaction with U5 snRNA and can stimulate DNA nonhomologous end joining (NHEJ) through the interaction with ku70/G22p and ku80/XRCC5 dimers. Alternate names for NONO include 54kD nuclear RNA- and DNA-binding protein, p54 (nrb), 55kD nuclear protein, NMT55, DNA-binding p52/p100 complex, NRB54, P54, and P54NRB.
Catalog #N3520-02A
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.1-0.3ug/ml
ELISA: 1:16,000
Immunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide C-NRAAPGAEFAPNK from the C-terminus of human NONO.
SpecificityRecognizes human NONO. Species sequence homology: canine, rat and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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