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You are here:Home » Antibodies » Abs to RNA Processing » Anti -NONO (Non-POU Domain-containing Octamer-binding Protein, NonO Protein, 54 kDa Nuclear RNA- and DNA-binding Protein, 55 kDa Nuclear Protein, DNA-binding p52/p100 Complex, 52 kDa Subunit, NMT55, p54(nrb), p54nrb, NRB54)

Anti -NONO (Non-POU Domain-containing Octamer-binding Protein, NonO Protein, 54 kDa
Nuclear RNA- and DNA-binding Protein, 55 kDa Nuclear Protein, DNA-binding p52/p100
Complex, 52 kDa Subunit, NMT55, p54(nrb), p54nrb, NRB54)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IH IC
p54nrb (NONO) is a DNA- and RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing (1). As part of the splicesomal complex, PTB-associated RNA splicing factor (PSF) and p54nrb are essential for both step I and II pre-mRNA splicing reactions (2). p54nrb is a component of the SFPQ-NONO complex, which is associated with MATR3 and plays a role in nuclear retention of defective RNA’s. The complex is involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (3). A rearrangement between p54nrb and the transcription factor E3 has been observed in papillary renal cell carcinoma.
Catalog #N3520-04
ApplicationsSuitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000-1:10,000
Immunohistochemistry: 1:250-1:500
Immunocytochemistry: 1:250-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone NoEPR5270
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues at the C-terminus of human NONO.
SpecificityRecognizes human NONO.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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