Anti -NOS1 (Nitric Oxide Synthase, Brain, Constitutive NOS, NC-NOS, NOS Type I, Neuronal
NOS, N-NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1, bNOS)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| NOS are multifunctional hemoproteins catalyzing the synthesis of Nitric oxide from L- Arginine. These are bidomain enzymes and contain an N-terminal oxidase domain with P450-type heme active site and a BH4 binding site, a central CAM-binding motif, and a C-terminal reductase domain with an electron-transfer motif which binds FMN and FAD. NOS1, a neuronal isoform of NOS, is mainly expressed in neuronal tissues and skeletal muscle & consists of a unique N-terminal PDZ domain which mediates protein-protein interactions. It participates in diverse biological processes which include neurotransmission, neuroendocrine physiology, regulation of body fluid homeostasis, macula densa signaling, and control of smooth muscle motility, cardiac contractility, sexual function and myocyte/myoblast biology. It is activated due to Ca2+/ CAM interactions. Multiple factors including PIN, PKC, PKA, Hsp90, Calveolin 3 and CAM Kinases tightly regulate NOS1 activity and its role has been implicated in DMD and myopathies. | | | Catalog # | N5350-01Q | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa19-31 [PRKGPPLPNGDTEC] of NOS. | | Specificity | Recognizes human NOS1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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