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You are here:Home » Antibodies » Abs to Nitric Oxide » Anti -NOS1 (Nitric Oxide Synthase, Brain, Constitutive NOS, NC-NOS, NOS Type I, Neuronal NOS, N-NOS, nNOS, bNOS, Peptidyl-cysteine S-nitrosylase NOS1)

Anti -NOS1 (Nitric Oxide Synthase, Brain, Constitutive NOS, NC-NOS, NOS Type I, Neuronal
NOS, N-NOS, nNOS, bNOS, Peptidyl-cysteine S-nitrosylase NOS1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Nitric Oxide Synthase 1(NOS1, neuronal NOS, nNOS1) is a messenger molecule, mediating the effect ofendothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain. It may be involved in neuronal cell death and damage in neurological illness. nNOS1 localized to the 12q24.2 region of human chromosome 12. It splice variant, expressed in testis, that encodes an NH2-terminal truncated protein of 1098aa. nNOS cDNA clones were shown to contain different 5' terminal exons spliced to a common exon 2.Genomic cloning and sequence analysis demonstrate that the unique exons are positioned within 300bp of each other but separated from exon 2 by an intron that is at least 20kb in length. The neuronal isoform of nitric oxide synthase is highly expressed in mammalian skeletal muscle, it suggested a specific role for NOS1 in the local metabolic inhibition of alpha-adrenergic vasoconstriction in active skeletal muscle. The novel gaseous neuromediator nitric oxide is thought to play an important role in development and plasticity. Despite this, gene-knockout mice lacking neuronal (Type I) nitric oxide synthase exhibit relatively normal brain development and behavior.
Catalog #N5350-03L
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Immunohistochemistry: 2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in 5mg BSA, 0.9mg sodium chloride, 0.2mg disodium hydrogen phosphate, 0.05mg thimerosal, 0.05mg sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 1418-1434aa from human NOS1 at C-terminal.
SpecificityRecognizes human NOS1. Species Crossreactivity: Rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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