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Abs to Notch Proteins
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Anti -Notch3 (Notch homolog 3, Drosophila, hN3, CASIL, CADASIL)
Anti -Notch3 (Notch homolog 3, Drosophila, hN3, CASIL, CADASIL)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH |
|
| The Notch protein sits like a trigger penetrating the cell membrane, with part of it inside and part outside. Proteins when binding to the exterior part cause the release of a portion of the interior part, which typically then makes its way to the cell nucleus to alter gene expression. The Notch gene belongs to a family of epidermal growth factor (EGF)-like homeotic genes, which encode transmembrane proteins with a variable number of cysteine rich EGF like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1,Notch2, Notch3 and Notch4(Int3), which have been implicated in the differentiation of the nervous system and other structures. The EG- like proteins Delta and Serrate have been identified as ligands of Notch1. | | | Catalog # | N5375-26A | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Immunohistochemistry: 1:100-1:300 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic peptide corresponding to the C-terminal region of the human NOTCH homolog 3 (NOTCH3) protein. | | Specificity | Recognizes human Notch3. Species Crossreactivity: rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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