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You are here:Home » Antibodies » Abs to Notch Proteins » Anti -Notch3 (Neurogenic Locus Notch Homolog Protein 3, Notch 3, Notch-3) (PerCP)

Anti -Notch3 (Neurogenic Locus Notch Homolog Protein 3, Notch 3, Notch-3) (PerCP)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early event developmental processes. The extracellular domains of Notch receptors interact with the extracellular domains of the transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. In both vertebrates and invertebrates, Notch signaling is important for specifying cell fates and for defining boundaries between different cell types. Notch-3 has the same biochemical mechanism of signal transduction as Notch-1, where a series of cleavage events release the Notch intracellular domain (NICD). NICD translocates to the nucleus and initiates transcription of Notch responsive genes. Thus, Notch acts as both a ligand binding receptor and a nuclear factor that regulates transcription. Human Notch-3 shows 90% aa identity to mouse Notch-3 over the entire protein.
Catalog #N5375-27F
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Absorption 482nm and 564nm (maximum)
Emission 675nm (maximum)
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. PerCP conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1
Clone No12K144
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with PerCP.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant corresponding to aa40-467 from human Notch-3 expressed in Sf21 cells.
SpecificityRecognizes human Notch-3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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