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You are here:Home » Biochemicals » Biochem-Antibiotics » Novobiocin



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Novobiocin is an aminocoumarin antibiotic isolated from a number of species of Streptomyces. Novobiocin exhibits broad spectrum Gram +ve activity and was used clinically. Novobiocin is a potent inhibitor of bacterial DNA gyrase and acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.
Catalog #N5376-61
SourceNovobiocin from Stretomyces sp.
Molecular Weight~612.6
SolubilitySoluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number303-81-1
Molecular FormulaC31H36N2O11
Molecular Weight~612.6
Purity~95% (HPLC)
ConcentrationNot determined
FormSupplied as a pale yellow solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

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