USBio Logo

N5376-77B Rabbit Anti-NOX4 (NADPH Oxidase 4, NOX-4, Renal NAD(P)H-Oxidase, RENOX, Kidney Superoxide-producing NADPH oxidase, KOX-1) (Biotin)

Specifications
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9NPH5
Conjugate
Biotin
Isotype
IgG
Grade
Affinity Purified
Applications
IHC WB
Crossreactivity
Bo Hu Mk Mo Rt Sh
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze
EC=1.6.3

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggest that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.

Applications
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Western Blot: 2ug/ml, recognizes a band at ~67 kD, representing isoform 1. immunohistochemistry 5 ug/ml Optimal dilution determined by the researcher.
Storage and Stability
May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
A synthetic peptide made to a region within residues 100-200 of the human NOX4 protein sequence. Cellular Localization: Endoplasmic reticulum, endoplasmic reticulum membrane, multi-pass membrane protein, cell membrane, nucleus (probable).
Form
Supplied as a liquid in Tris-citrate-phosphate, pH 7-8, no preservativeadded.
Purity
Purified by immunoaffinity chromatography.|
Specificity
Recognizes human NOX4. Species Homology: 100% human, mouse, rat, cow, sheep, and monkey proteins.
Conjugates
Pricing
Order
Proceed to Checkout
Cart Summary
ProductSizeListYour PriceQtyExt Price
Subtotal:Subtotal:
Subtotal:Subtotal:
Total Coupon Savings:Total Coupon Savings:()
Your cart is currently empty.
- Coupon Code
Recently Viewed
Contact Us

Visit our technical library or contact our support staff to answer your questions.

Telephone:
1-800-520-3011

Library | Contact

Distributors

For customers outside of the United States, please use one of our many distributors.

View Distributors

Payment Methods

We accept the following payment methods as well as pay-by-invoice.

MasterCard Visa PayPal
© 2023-2024 United States Biological - All Rights Reserved