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You are here:Home » Antibodies » Abs to Defensin » Anti -NP-5 (Alpha Defensin 5, Defensin 5, DEF5, Defensin alpha 5, Defensin alpha 5 Paneth Cell-specific, Defensin alpha 5 Preproprotein, DEFA5, HD5, HD-5, HNP5, HNP-5, MGC129728)

Anti -NP-5 (Alpha Defensin 5, Defensin 5, DEF5, Defensin alpha 5, Defensin alpha 5 Paneth
Cell-specific, Defensin alpha 5 Preproprotein, DEFA5, HD5, HD-5, HNP5, HNP-5, MGC129728)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH IF
Human neutrophil alpha-defensins (also designated HNPs) are small, cationic, cysteine-rich antimicrobial proteins that play important roles in innate immunity against infectious microbes such as bacteria, fungi and enveloped viruses. Alpha-defensins are synthesized as inactive precursors and are activated by proteolytic cleavage by MMP-7. In the mature form, NP-5 is cleaved at residue 63 (alanine). Paneth cells in small intestinal crypts secrete the alpha-defensins, which are also termed cryptidins in mice. Alpha-defensins 5 and 6 probably contribute to innate defense of the GI mucosal surface by protecting against microbial invasion in states of intestinal inflammation.
Catalog #N5378-07B
ApplicationsSuitable for use in Immunofluorescence, ELISA, Western Blot. Dot Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (FFPE): 5-10ug/ml
Immunohistochemistry (Frozen): 5-10ug/ml
Western Blot: 1:1000
Immunofluorescence (IC): 1:200-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No9A8
HostMouse
SourceHuman
Concentration~2mg/ml
FormSupplied as a liquid in Tris-glycine, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography
ImmunogenFull-length proHD5 protein [Swiss-Prot# Q01523]. The propeptide is the full-length protein. In the mature form it is cleaved at residue 63 (alanine). Cellular Localization: Secreted.
SpecificityRecognizes human HD5 at ~10kD. No crossreactivity is observed with HD6, lysozyme or sPLA2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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