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You are here:Home » Antibodies » Abs to Defensin » Anti -NP-5 (Alpha Defensin 5, Defensin 5, DEF5, Defensin alpha 5, Defensin alpha 5 Paneth Cell-specific, Defensin alpha 5 Preproprotein, DEFA5, HD5, HD-5, HNP5, HNP-5, MGC129728)

Anti -NP-5 (Alpha Defensin 5, Defensin 5, DEF5, Defensin alpha 5, Defensin alpha 5 Paneth
Cell-specific, Defensin alpha 5 Preproprotein, DEFA5, HD5, HD-5, HNP5, HNP-5, MGC129728)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IH
Human neutrophil alpha-defensins (also designated HNPs) are small, cationic, cysteine-rich antimicrobial proteins that play important roles in innate immunity against infectious microbes such as bacteria, fungi and enveloped viruses. Alpha-defensins are synthesized as inactive precursors and are activated by proteolytic cleavage by MMP-7. Paneth cells in small intestinal crypts secrete the alpha-defensins, which are also termed cryptidins in mice. Alpha-defensins 5 and 6 probably contribute to innate defense of the GI mucosal surface by protecting against microbial invasion in states of intestinal inflammation
Catalog #N5378-07C
ApplicationsSuitable for Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Paraffin only): 5-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No9i248
HostMouse
SourceHuman
Concentration~2mg/ml
FormSupplied as a liquid in Tris-glycine, 150mM sodium chloride with 0.05% sodium azide.
PurityPurified immunoglobulin
ImmunogenFull-length proHD5 protein. [Swiss-Prot# Q01523] The propeptide is the full-length protein. In the mature form, it is cleaved at residue 63 (alanine).
SpecificityRecognizes human Defensin 5.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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