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You are here:Home » Antibodies » Abs to Nuclear Proteins » Anti -NUP98 (ADIR2, Nuclear pore complex protein Nup98-Nup96 precursor, NUP196)

Anti -NUP98 (ADIR2, Nuclear pore complex protein Nup98-Nup96 precursor, NUP196)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186kD precursor protein. This cleavage results in the 98kD nucleoporin as well as a 96kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Catalog #N5378-61B
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a, k
Clone No4G2
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified.
ImmunogenNUP98 (AAH12906, 1-110aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human NUP98.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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