You are here:Home
»
Antibodies
»
Abs to Ion Channel
»
Anti -NR1, phosphorylated (Ser896) (NMDA Receptor, N-methyl-D-aspartate Receptor)
Anti -NR1, phosphorylated (Ser896) (NMDA Receptor, N-methyl-D-aspartate Receptor)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH FC |
|
| NR1 (NMDA1or NMDAR1, also known as GRIN1) along with the NR2 subunit forms a heterodimer that make up the NMDA receptor. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory. | | | Catalog # | N5380-08 | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested. | | Recommended Dilutions | | | Western Blot: 1ug/ml detects NR1 on 10ug of lambda phosphatase untreated and treated rat microsomal brain tissue lysates. | | Immunohistochemistry: 1:25 detects NR1 in normal rat hippocampus tissue. | | Optimal dilutions to be determined by the researcher. | | Positive Control | Lambda phosphatase untreated and treated rat microsomal brain tissue lysates | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Rat | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150 mM sodium chloride, 0.05% sodium azide. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic peptide corresponding to rat NR1 phosphorylated at Ser896 (KLH). Epitope: Phosphorylated Ser896 | | Specificity | Recognizes rat NR1 when phosphorylated at Ser896. Species sequence homology: human, mouse 100%. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
