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You are here:Home » Antibodies » Abs to Ion Channel » Anti -NR1, phosphorylated (Ser896) (NMDA Receptor, N-methyl-D-aspartate Receptor)

Anti -NR1, phosphorylated (Ser896) (NMDA Receptor, N-methyl-D-aspartate Receptor)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH FC
NR1 (NMDA1or NMDAR1, also known as GRIN1) along with the NR2 subunit forms a heterodimer that make up the NMDA receptor. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory.
Catalog #N5380-08
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1ug/ml detects NR1 on 10ug of lambda phosphatase untreated and treated rat microsomal brain tissue lysates.
Immunohistochemistry: 1:25 detects NR1 in normal rat hippocampus tissue.
Optimal dilutions to be determined by the researcher.
Positive ControlLambda phosphatase untreated and treated rat microsomal brain tissue lysates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
Concentration~0.5mg/ml
FormSupplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150 mM sodium chloride, 0.05% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to rat NR1 phosphorylated at Ser896 (KLH). Epitope: Phosphorylated Ser896
SpecificityRecognizes rat NR1 when phosphorylated at Ser896. Species sequence homology: human, mouse 100%.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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