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You are here:Home » Molecular Biology » MB-Neurotrophins » NT-4, Recombinant, Human (Neurotrophin 4)

NT-4, Recombinant, Human (Neurotrophin 4)


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Neurotrophin-4 (NT-4/NT-5) is a potent neurotrophic factor which supports the growth and survivability of nerve and/or glial cells. NT-4 is a neurotrophic factor structurally related to beta-NGF, BDNF and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors and promotes the survival of peripheral sensory sympathetic neurons. The active form of human NT-4 is a dimer, formed by two identical 130 amino acid subunits, which is held together by strong hydrophobic interactions. Recombinant human NT-4 is a noncovalently linked homodimer, of two 14.0kD polypeptide monomers (260 total amino acid residues).
Catalog #N6000-11
Endotoxin< 0.1ng/ug (1EU/ug)
Responding Cells (partial list) Nerve, glial cells
Biological ActivityThe ED50 was determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found in the range of 20-50ng/ml
Concentration Range for most in vitro applications 0.5-100ng/ml
ReconstitutionReconsitute with water to a concentration of 0.1-1.0mg/ml.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile water and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Country of OriginUSA
Molecular Weight28.1kD
SourceE. coli
Purity> 98% by SDS-PAGE and HPLC analyses
FormSupplied as a lyophilized protein with no additives.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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