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You are here:Home » Antibodies » Abs to Neurotrophins » Anti -NT-4 Propeptide (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)

Anti -NT-4 Propeptide (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4,
Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic
Factor 5, NTF5)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
NT-4 Propeptide (neurotrophin-4/5) is a 27kD, secreted, glycosylated neuronal polypeptide that belongs to the NGF-b family of neurotrophic factors. It is synthesized as a proform that contains a 9kD, 56aa proregion (aa25-80) and a 130aa mature segment. The mature molecule forms both nondisulfide linked heterodimers (with NGF) and homodimers. It is unclear if 186aa NT-4 Propeptide dimerizes, but this might be anticipated. Proneurotrophins are believed to activate NGFR and sortilin complexes and neurotrophin proregions regulate neurotrophin maturation. Over aa25-80, human NT-4 Propeptide is 89% and 91% aa identical to mouse and canine NT-4 Propeptide, respectively.
Catalog #N6000-12C
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.5-1ug/ml
Western Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C for short-term only. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenE. coli-derived recombinant human Neurotrophin-4 Propeptide (aa25-80; Accession # P34130).
SpecificityRecognizes human NT-4 Propeptide. Cross-reactivity with mature NT-4 is <1%. Species sequence homology: mouse (89%), canine (91%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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