NT-4 Propeptide (neurotrophin-4/5) is a 27kD, secreted, glycosylated neuronal polypeptide that belongs to the NGF-b family of neurotrophic factors. It is synthesized as a proform that contains a 9kD, 56aa proregion (aa25-80) and a 130aa mature segment. The mature molecule forms both nondisulfide linked heterodimers (with NGF) and homodimers. It is unclear if 186aa NT-4 Propeptide dimerizes, but this might be anticipated. Proneurotrophins are believed to activate NGFR and sortilin complexes and neurotrophin proregions regulate neurotrophin maturation. Over aa25-80, human NT-4 Propeptide is 89% and 91% aa identical to mouse and canine NT-4 Propeptide, respectively.
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