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Specifications

Clone Host Grade Applications Polyclonal Chicken Purified E B

NT-4 Propeptide (neurotrophin-4/5) is a 27kD, secreted, glycosylated neuronal polypeptide that belongs to the NGF-b family of neurotrophic factors. It is synthesized as a proform that contains a 9kD, 56aa proregion (aa25-80) and a 130aa mature segment. The mature molecule forms both nondisulfide linked heterodimers (with NGF) and homodimers. It is unclear if 186aa NT-4 Propeptide dimerizes, but this might be anticipated. Proneurotrophins are believed to activate NGFR and sortilin complexes and neurotrophin proregions regulate neurotrophin maturation. Over aa25-80, human NT-4 Propeptide is 89% and 91% aa identical to mouse and canine NT-4 Propeptide, respectively.
Catalog #	N6000-25C
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Recommended Secondary Antibodies	I1906: IgY, Chicken Pab Rb xCh
	I1906-10: IgY, Chicken (HRP) Rb xCh
	I1906-12: IgY, Chicken (FITC) Rb xCh
	I1906-14: IgY, Chicken (AP) Rb xCh
	I1906-01: IgY, (HRP) Gt xCh
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone Type	Polyclonal
Isotype	IgY
Host	Chicken
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid.
Purity	Purified by precipitation.
Immunogen	Human NT-4,5 mixed peptides
Specificity	Recognizes human NT4/5. Species Crossreactivity: Mouse
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.