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You are here:Home » Antibodies » Abs to Disease Markers » Anti -NTAL (Non-T Cell Activation Linker, HSPC046, Linker for Activation of B cells, LAB, Lat2, Membrane Associated Adapter Molecule, Williams Beuren Syndrome Chromosome Region 5, WBSCR5, WSCR5, WBSCR15)

Anti -NTAL (Non-T Cell Activation Linker, HSPC046, Linker for Activation of B cells, LAB,
Lat2, Membrane Associated Adapter Molecule, Williams Beuren Syndrome Chromosome Region 5,
WBSCR5, WSCR5, WBSCR15)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH IF
Alternatively termed as linker for activation of B cells (LAB), NTAL is expressed in plasma membrane lipid rafts of B cells, mast cells, monocytes and NK cells. The engagement and activation of antigen receptors on B and T lymphocytes initiates signal transducing pathways that are vital for the successful initiation of an adaptive immune response. It is following the cross-linking of the B cell receptor (BCR) or high-affinity FE receptors of myeloid cells, that the tyrosine phosphorylation of NTAL occurs, enabling the formation of complexes between NTAL and further signaling molecules Grb2, Gab1, Sos1 and c-Cbl. Recent studies into the functions of NTAL, have indicated that this molecule may also act as a negative regulator of mast cell Fc Epsilon RI-mediated signalling.
Catalog #N6000-26C
ApplicationsSuitable for use in Western Blot, Immunofluorescence and Immunohistochemistry (Frozen). Other applications not tested.
Recommended DilutionWestern Blot: Non-reducing, detects a band of approximately 30kD in Ramos cell lysates.
Optimal dilution determined by the researcher.
Recommended Secondary ReagentsF(ab')2 rabbit anti mouse IgG:HRP
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6A454
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
PurityPurified by protein A affinity chromatography.
ImmunogenRecombinant cytoplasmic domain (aa 91-244) of human NTAL.
SpecificityRecognizes non T-cell activation linker (NTAL), a 30kD transmembrane adaptor protein that is structurally related to the T cell adaptor protein LAT. Species Cross Reactivity:Human, Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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