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You are here:Home » Antibodies » Abs to Enzymes, Endonuclease » Anti -NTH (Endonuclease III Like 1, NTHL1, OCTS3)

Anti -NTH (Endonuclease III Like 1, NTHL1, OCTS3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B
Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites (2).
Catalog #N6000-27
A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA (3).
Application(s)Suitable for use in Western Blot where a band at ~37kD is seen on SDS-PAGE. Other applications not tested.
Recommended DilutionWestern Blot: 1:1,000-1:5,000 (ECL)
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 0.1% sodium azide.
PuritySerum
ImmunogenFull-length recombinant protein (human)
SpecificitySpecific for human NTH protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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