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You are here:Home » Antibodies » Abs to Enzymes, Endonuclease » Anti -NTH1 (E. coli Endonuclease III Homologue)

Anti -NTH1 (E. coli Endonuclease III Homologue)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites. A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.
Catalog #N6000-28
Positive control K562 cell extracts , Hela cell extracts.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenA peptide derived from the human NTH1.
SpecificitySpecific for NTH1. Species crossreactivity: Reacts with human NTH1. There is sequence homology to mouse.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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