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You are here:Home » Antibodies » Abs to Receptors » Anti -NR1D2 (Nuclear Receptor Subfamily 1 Group D Member 2, Rev-erb-beta, V-erbA-Related Protein 1-Related, EAR-1R, Orphan Nuclear Hormone Receptor BD73)

Anti -NR1D2 (Nuclear Receptor Subfamily 1 Group D Member 2, Rev-erb-beta, V-erbA-Related
Protein 1-Related, EAR-1R, Orphan Nuclear Hormone Receptor BD73)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Rev-erbA beta, a NR1 Thyroid Hormone-Like Receptor, has been shown to affect cell proliferation, organ physiology, and myogenesis. Rev-erbA beta has been shown to be a constitutive repressor and binds as a monomer or homodimer to target DNA, such as the n-myc gene. Rev-erbA beta has also been shown to repress the human apoCIII gene, therefore underscoring a physiological role in the regulation of genes involved in triglyceride metabolism and the pathogenesis of atherosclerosis. Two isoforms of Rev-erbA beta have been isolated in rats (Rev-erbA beta 1 and Rev-erbA beta 2). Rev-erbA beta 2 is longer than Rev-erbA beta 1 by 195aa. Rev-erbA beta expression has been documented in animal brain, skeletal muscle, embryo, and spleen, and in human skeletal muscle. ESTs have been isolated from human tissue libraries, including cancerous brain, colon, eye, kidney, lung, prostate, skin, and uterus, and normal brain, colon, embryo, heart, kidney, liver, lung, nerve, pineal, placenta, skeletal muscle, testis, tonsil, and uterus.
Catalog #N6889-86D
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human REVB at C-terminal (KLH).
SpecificityRecognizes human REVB. Species sequence homology: Mouse and rat (100%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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