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Anti -Nucleophosmin (NPM, B23, Numatrin, Nucleolar protein NO38, Nucleolar Phosphoprotein B23, NPM1) (Azide Free)
Anti -Nucleophosmin (NPM, B23, Numatrin, Nucleolar protein NO38, Nucleolar Phosphoprotein
B23, NPM1) (Azide Free)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH IF |
|
| NPM1 is a ubiquitously expressed nucleolar protein that shuttles between the nucleus and cytoplasm. It is implicated in multiple functions, including ribosomal protein assembly and transport, control of centrosome duplication, and regulation of the tumor suppressor ARF (MIM 600160). NPM1 mutations that relocalize NPM1 from the nucleus into the cytoplasm are associated with development of acute myeloid leukemia (AML; MIM 601626) (Garzon et al., 2008 [PubMed 18308931]).[supplied by OMIM] | | | Catalog # | N7100-15B | | Applications | Suitable for use in ELISA, Immunofluorescence, Immunohistochemistry (paraffin), and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1ug/ml-3ng/ml | | Western Blot: 1:500-1:1,000 | | Immunohistochemistry (paraffin): 1.5ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11C502 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free). | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant protein corresponding to full-length (aa1-295) human NPM coupled to glutathione S transferase (GST). | | Specificity | Recognizes human NPM. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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