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You are here:Home » Antibodies » Abs to Nuclear Proteins » Anti -Nucleoporin (NUP96, Nuclear Pore Complex Protein Nup98-Nup96, NUP98, ADIR2, NUP96, NUP196)

Anti -Nucleoporin (NUP96, Nuclear Pore Complex Protein Nup98-Nup96, NUP98, ADIR2, NUP96,
NUP196)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IH IC
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186kD precursor protein. This cleavage results in the 98kD nucleoporin as well as a 96kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. NUP96 has been shown to fuse to several proteins through mutations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). It is an important tumor-suppressor protein. Mutations in NUP96 have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.
Catalog #N7100-54G4
ApplicationsSuitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000-1:10,000
Immunohistochemistry: 1:50-1:100
Immunocytochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone NoEPR6678
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues in human NUP96.
SpecificityRecognizes human NUP96 (NUP98).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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