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NVP-BEZ235, Free Base (4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-alpha,alpha-dimethyl-benzeneacetonitrile, BEZ235)
NVP-BEZ235, Free Base
(4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-alpha,alph
a-dimethyl-benzeneacetonitrile, BEZ235)
Pricing
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| NVP-BEZ235 is an imidazo[4,5-c]quinoline derivative that inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. NVP-BEZ235 is able to effectively and specifically block the dysfunctional activation of the PI3K pathway and induce G(1) arrest. It also inhibits the growth of human cancer in animal models. | | | Catalog # | N8569-60 | | Solubility | Soluble in anhydrous dimethylformamide at 10mg/ml after warming to 75ºC and cooling; soluble in DMSO at 1.33mg/ml with warming; soluble in 1-methyl-2-pyrrolidinone at about 2mg/ml if heated in a 75ºC bath and cooled; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20uM; buffers, serum or other additives may increase or decrease the aqueous solubility. | | Melting Point | 282.5-285ºC | | Elemental Analysis | Calculated | | C: 76.74% | | H: 4.94% | | N: 14.92% | | Storage and Stability | May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. | | CAS Number | 915019-65-7 | | Molecular Formula | C30H23N5O | | Molecular Weight | 469.54 | | Purity | ~99% | | Form | Supplied as a white to off-white powder | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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