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You are here:Home » Antibodies » Abs to Nuclear Proteins » Anti -NXP-2 (Nuclear Matrix Protein NXP-2)

Anti -NXP-2 (Nuclear Matrix Protein NXP-2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
NXP-2 is a unique mammalian nuclear protein expressed in specific tissues and has specific RNA binding function. NXP-2 is a member of the MORC protein family characterized by conserved structures consisting of a GHL (Gyrase B, Hsp90 and MutL)-ATPase domain at the amino-terminus, a zinc finger type CW domain containing conserved four cysteines and two tryptophans, a nuclear localization signal (NLS) and coiled-coil domains at the carboxy-terminus. The protein is localized in the nucleus and distributed to the nuclear matrix. Apart from RNA binding activity, the protein also plays important roles in diverse nuclear functions, including RNA metabolism and maintenance of nuclear architecture. A recent study has confirmed the role of the protein in SUMO-mediated repression of transcription. NXP-2 also regulates the activity of tumor suppressor protein, p53 and its localization into promyelocytic leukemia (PML)-nuclear bodies. Human NXP-2 gene is located at chromosome 21q22.13.
Catalog #N8569-88
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum.
ImmunogenSynthetic peptide corresponding to aa321-338 (NRLIKAYEKVGCQLRANN) of human NXP-2.
SpecificityRecognizes human NXP-2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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