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N8574-10 Rabbit Anti-NYREN18, NT (NEDD8 Ultimate Buster-1, NUB1, Negative Regulator Of Ubiquitin-like Proteins 1, Renal Carcinoma Antigen NY-REN-18, NUB1)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9Y5A7
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu Mo
Accession #
NP_057202
Shipping Temp
Blue Ice
Storage Temp
-20°C

NYREN18 is a specific down-regulator of the NEDD8 conjugation system. It recruits NEDD8 and its conjugates to the proteasome for degradation. It also interacts with PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome.

Applications
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-1:500 Immunohistochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide selected from the N-terminal region of human NYREN18 (KLH).
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes human NYREN18. Species Crossreactivity: mouse.
References
1. Tanaka, T., et al., J. Biol. Chem. 278(35):32905-32913 (2003). 2. Strausberg, R.L., et al., Proc. Natl. Acad. Sci. USA 99(26):16899-16903 (2002). 3. Kito, K., et al., J. Biol. Chem. 276(23):20603-20609 (2001). 4. Kamitani, T., et al., J. Biol. Chem. 276(49):46655-46660 (2001). 5. Scanlan, M.J., et al., Int. J. Cancer 83(4):456-464 (1999).
USBio References
No references available
Conjugates
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