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You are here:Home » Antibodies » Antibodies-Ion Channel » Anti -OATP2 (Organic Anion Transporting Polypeptide 2)

Anti -OATP2 (Organic Anion Transporting Polypeptide 2)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs and other organic anions from the blood by a process called “renal secretion.” Besides kidney, anionic substrates are also transported in other organs, e.g., choroid plexus, eye, airway and placenta. Several multispecific OATs (OAT1-3, OAT-K1, OATK2) and OATPs (oatp1-3, LST-1, and PGT), have been cloned and characterized from various tissues. OATPs family of proteins share significant sequence homology, and general secondary protein structure (up to 12 transmembrane domains with cytoplasmic N and C-terminus). OAT2, previously called NLT (novel liver-specific transporter) shows 42% homology with OAT2. OAT2 (rat 535 aa; human 548 aa) is predominantly expressed in liver, and to a lower level in kidney. OAT2 mediates sodium-independent, multispecific organic anion transport (PAH, salicylate and acetylsalicylate, prostaglandin E2, and dicarboxylate).
Catalog #O3001-09
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsELISA: 0.5-1ug/ml
Western Blot: 1-10ug/ml using ECL.
Immunohistochemistry (paraformaldehyde fixed): 2-20ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.4, 0.1% BSA.
PurityPurified by affinity chromatography.
ImmunogenA synthertic peptide corresponding to 15aa near the N-terminus, extracellular domain of rat OATP2 (035913), conjugated to KLH. Species Sequence Homology: mouse; 85%, human OATP 73%.
SpecificityRecognizes rat OATP2 (Organic Anion Transporting Polypeptide 2). No significant sequence homology is detected with other OATs or other proteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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