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You are here:Home » Antibodies » Abs to Obesity Proteins » Anti -Obestatin (Appetite-regulating Hormone, Growth Hormone Secretagogue, Growth Hormone-releasing Peptide, Motilin-related Peptide, Protein M46, Ghrelin, GHRL, MTLRP, UNQ524/PRO1066)

Anti -Obestatin (Appetite-regulating Hormone, Growth Hormone Secretagogue, Growth
Hormone-releasing Peptide, Motilin-related Peptide, Protein M46, Ghrelin, GHRL, MTLRP,
UNQ524/PRO1066)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B
Control of appetite involves a number of gastrointestinal hormones that belong to the ghrelin-motilin ligand family that either stimulate food intake and gastric emptying or inhibit these responses.
Catalog #O4802-20A
Recently, a new member of the ghrelin-motilin family was identified by using bioinformatic predictions about enzyme cleavage of the prepropeptide of ghrelin. The newly identified 23aa, ghrelin-associated peptide was named obestatin. Although both peptides originate from the same precursor prepropeptide, they have opposing physiological roles. Obestatin exerts anorexigenic effects by decreasing food intake, gastric emptying, jejunal motility, and weight gain by binding to GPR39 orphan receptor, while ghrelin exerts opposing orexigenic effects by binding to growth hormone secretagogue receptor. Reports that GPR39 is a cognate receptor for Obestatin were recently contradicted warning for more prudent approach to investigation.
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:100,000
Western Blot: 1-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a lyophilized powder from PBS, 0.05% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to 13aa of human OBSN1 (Accession #Q9UBU3), N-terminal, extracellular (KLH).
SpecificityRecognizes human Obestatin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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