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You are here:Home » Antibodies » Abs to Obesity Proteins » Anti -Obestatin (Appetite-regulating Hormone, Growth Hormone Secretagogue, Growth Hormone-releasing Peptide, Motilin-related Peptide, Protein M46, Ghrelin, GHRL, MTLRP)

Anti -Obestatin (Appetite-regulating Hormone, Growth Hormone Secretagogue, Growth
Hormone-releasing Peptide, Motilin-related Peptide, Protein M46, Ghrelin, GHRL, MTLRP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Control of appetite involves a number of gastrointestinal hormones that belong to the ghrelin-motilin ligand family that either stimulate food intake and gastric emptying or inhibit these responses.
Catalog #O4802-21
Recently, a new member of the ghrelin-motilin family was identified by using bioinformatic predictions about enzyme cleavage of the prepropeptide of ghrelin. The newly identified 23aa, ghrelin-associated peptide was named obestatin. Although both peptides originate from the same precursor prepropeptide, they have opposing physiological roles. Obestatin exerts anorexigenic effects by decreasing food intake, gastric emptying, jejunal motility, and weight gain by binding to GPR39 orphan receptor, while ghrelin exerts opposing orexigenic effects by binding to growth hormone secretagogue receptor.
Obestatin Human, mouse, rat 23aa each - 2.6kD; mouse Chromosome: 6E3. Mainly expressed in the gastrointestinal tract with higher levels in the stomach, medium levels in the duodenum, jejunum, ileum and colon. Low expression in the testis and brain. Not detected in the salivary gland, pancreas, liver and lung.
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:100,000
Western Blot: 1-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a lyophilized powder from PBS, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 23aa of mouse Obestatin (Accession #Q9EQX0), N-terminal, extracellular (KLH).
SpecificityRecognizes mouse Obestatin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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