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O5800 Okadaic Acid, Sodium salt (Halochondrine A) CAS: 209266-80-8

Specifications
References
Brand
BioReagent™
CAS Number
209266-80-8
Grade
Highly Purified
Molecular Formula
C44H68O13•Na
Molecular Weight
826.98
EU Commodity Code
38220090
UN DOT Shipping
UN 3462 PG I
Shipping Temp
Blue Ice
Storage Temp
-20°C
9,10-Deepithio-9,10-didehydroacanthifolicin, Halochondrine A

Okadaic Acid, a marine toxin, polyether derivative produced by dinoflagellates, is a potent, cell-permeable, specific inhibitor of PP-1 and PP-2 serine/threonine-specific protein phosphatases in a variety of cell types. Salt form of okadaic acid, with somewhat greater stability than the free acid when stored in organic solvents.

Source: Prorocentrum concavum
Solubility: Soluble in DMSO or ethanol.
Storage and Stability
Light Sensitive. Store at -20°C. Stable as a powder for at least 12 months. Stable as a liquid for 6 months.
WARNING: Highly irritant to skin and mucous membranes. SPECIAL HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.
Source
Prorocentrum concavum
Purity
Purified by preparative flash, medium pressure nad high performance liquid chromatography.
Form
Supplied as white powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
Haystead et al., Nature 337:78, 1989 |Redpath and Proud, Biochem. J. 262:69, 1989 |Takai, J. Mus. Res. & Cell Motil. 9:563, 1988 Wheat et al., Mol. Cell. Biol. 14:5881, 1994|Amara, F. M. et al.: Defining a Novel cis-Element in the 3’-Untranslated Region of Mammalian Ribonucleotide Reductase Component R2 mRNA. J. Biol. Chem. (1996) 271, 20126-20131: Cell culture.|Mimnaugh, E. G. et al.: Possible Role for Serine/Threonine Phosphorylation in the Regulation of the Heteroprotein Complex between the hsp90 Stress Protein and the pp60v-src Tyrosine Kinase. J. Biol. Chem. (1995) 270, 28654-28659: Cell culture.|Wheat, W.H. et al.: Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Mol. Cell. Biol. (1994) 14, 5881-5890: Inhibitor in protein phosphatase assay.|Trichostatin A (19-138) |El-Osta, A., et. al. Precipitous Release of Methyl-CpG Binding Protein 2 and Histone Deacetylase 1 from the Methylated Human Multidrug Resistance Gene (MDR1) on Activation. Molecular and Cellular Biology (2002) 22: 1844-1857. Chromatin Immunoprecipitation|Calyculin A (19-139) |Gautreau, A., et.al. Morphogenic Effects of Erzin Require a Phosphorylation Induced Transition from Oligomers to Monomers at the Plasma Membrane. The Journal of Cell Biology (2000) 150: 193-204. Serine/Threonine Inhibition|LY 294002 (19-142) |Wei, Q., et. al. Pitx2a Expression Alters Actin-Myosin Cytoskeleton and Migration of HeLa Cells through Rho GTPase Signaling. Mol. Biol. Cell (2002) 13: 683-697.PI3K Inhibition|PD 98059 (19-143) |Wei, Q., et. al. Pitx2a Expression Alters Actin-Myosin Cytoskeleton and Migration of HeLa Cells through Rho GTPase Signaling. Mol. Biol. Cell (2002) 13: 683-697. MEK1 Inhibition
USBio References
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