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You are here:Home » Antibodies » Abs to Enzymes, Protease (Proteinase, Peptidase) » Anti -Omi, HtrA2 (HtrA Serine Peptidase 2, High Temperature Requirement Protein A2, HtrA-like Serine Protease, Omi Stress-regulated Endoprotease, PARK13, Protease Serine 25, PRSS25, Serine Protease 25, Serine Protease HtrA2 Mitochondrial, Serine Protease Omi) (

Anti -Omi, HtrA2 (HtrA Serine Peptidase 2, High Temperature Requirement Protein A2,
HtrA-like Serine Protease, Omi Stress-regulated Endoprotease, PARK13, Protease Serine 25,
PRSS25, Serine Protease 25, Serine Protease HtrA2 Mitochondrial, Serine Protease Omi) (

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Serum E
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DAIBLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.
Catalog #O6350-01F1
Positive Control Jurkat or HL-60 cell lysate can also be used as a positive control.
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1, k
Clone No9A76
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PuritySerum
ImmunogenThis monoclonal antibody was developed by immunizing mice with a synthetic peptide containing amino acids 335-350 of human Omi/HtrA2.
SpecificityThis mAb does not crossreact with mouse Omi/HtrA2. Species Crossreactivity: Human
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesSerine Protease HtrA2 Mitochondrial Precursor


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