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You are here:Home » Biochemicals » Biochem-Antibiotics » Ophiobolin C (Zizzanin A)

Ophiobolin C (Zizzanin A)


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Ophiobolin C is a member of the ophiobolin class of phytotoxic metabolites produced by many species of the genus Bipolaris. Ophiobolin C is an inhibitor of human CCR5 binding to the envelope protein gp120 and CD4 that mediates HIV-1 viral entry into cells. Blockade of this binding was considered by scientists at Merck as a potentially new mode of action for the treatment of HIV-1 infection.
Catalog #O7024-02
Source Bipolaris sp. MST-FP245
Apperance White solid
Solubility Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number19022-51-6
Molecular FormulaC25H38O3
Molecular Weight386.6
SourceBipolaris sp. MST-FP245
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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