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Anti -Opioid Receptor, delta (OPRD1, Opioid Receptor delta, Delta-type Opioid Receptor, DOR-1, OPRD)
Anti -Opioid Receptor, delta (OPRD1, Opioid Receptor delta, Delta-type Opioid Receptor,
DOR-1, OPRD)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
E B |
|
| The function of the delta-opioid receptors has not been determined. However, recent studies in rodents have linked delta-opioid receptor antagonists with prevention of morphine tolerance and dependence without relinquishing mu-opioid antinociception. In general, opioids modulate numerous central and peripheral processes, including pain perception, neuroendocrine secretion and the immune response. The opioid signal is transduced from receptors through G proteins to various different effectors. Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal. For example, activation of opioid receptors increases phosphatidylinositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channel activities. | | | Catalog # | O7030-15D | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:8 with TBS/Tween-20, 1% normal goat serum. | | Optimal dilutions to be determined by the researcher. | | Included Control Peptide | O7030-15D1: Opioid Receptor, delta (360-372) | | Reconstitute with 600ul of reconstituted antibody. | | Peptide Amino Acid Sequence | Cys-Thr-Pro-Ser-Asp-Gly-Pro-Gly-Gly-Gly-Ala-Ala-Ala | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile TBS/Tween-20 containing 1% normal goat serum. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Concentration | Not determined | | Form | Supplied as a lyophilized powder. Reconstitution with 5.0 ml of TBS/Tween-20 containing 1% normal goat serum. | | Purity | Purified by precipitation, dialysis and chromatography. | | Immunogen | Peptide analog of the carboxyl terminal of the delta opioid receptor covalently attached onto a carrier protein. | | Specificity | Recognizes delta Opioid Receptor (360-372) and the reactivity of delta Opioid Receptor is ~60%. Does not react to Mu Opioid Receptor and Kappa Opioid Receptor. Has been found to stain specifically the delta opioid receptor in Western immunoblots of whole rat brain homogenates. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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