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You are here:Home » Antibodies » Abs to Opioid Receptors, Agonists » Anti -Opioid Receptor, mu, phosphorylated (Ser377) (MOR1)

Anti -Opioid Receptor, mu, phosphorylated (Ser377) (MOR1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP IF
The mu-opioid receptor (MOR) belongs to the superfamily of G-protein-coupled receptors. MOR mediates the analgesic and rewarding effects of morphine and other opiates as well as the actions of several endogenous opioid peptides (1). Upon binding to its ligands, this Gi-coupled receptor inactivates adenylyl cyclase and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Trafficking of these receptors to and from the plasma membrane and their desensitization play a significant role in morphine tolerance. As with other GPCRs, these processes are modulated by phosphorylation at diverse sites within intracellular domain. Among other sites, agonist-specific phosphorylation of serine 375 in mouse (serine 377 in human) MOR is essential for its internalization.
Catalog #O7030-51
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunofluorescence. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000
Immunoprecipitation: 1:100
Immunofluorescence (IF-F): 1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified by Protein A and peptide affinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to residues around Ser377 of human mu-Opioid Receptor. Sequence is homologous to Ser375 of mouse. MW: 70-90kD.
SpecificityRecognizes transfected mu-Opioid Receptor only when phosphorylated at serine 377 of human MOR (or serine 375 of mouse MOR). Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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