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You are here:Home » Antibodies » Abs to Membrane Proteins » Anti -ORAI1 (Transmembrane Protein 142A, TMEM142A, Calcium Release-Activated Calcium Channel Protein 1)

Anti -ORAI1 (Transmembrane Protein 142A, TMEM142A, Calcium Release-Activated Calcium
Channel Protein 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B IH
Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four- transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ++ ORAI1 functions as a highly selective Ca plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
Catalog #O7044-03A
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Immunohistochemistry: 10ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman ovary tissue lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified
ImmunogenSynthetic peptide corresponding to 18aa from human ORAI1, at N-terminal.
SpecificityRecognizes human ORAI1. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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