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Anti -ORAI1, ID (Transmembrane Protein 142A, TMEM142A, Calcium Release-Activated Calcium Channel Protein 1)
Anti -ORAI1, ID (Transmembrane Protein 142A, TMEM142A, Calcium Release-Activated Calcium
Channel Protein 1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| Calcium (Ca2+) entry into non-excitable cells is mainly carried by store- operated channels (SOCs), which serve essential functions ranging from regulation of transcription to cell growth. The store-operated current, ICRAC, is the calcium release-activated calcium (CRAC) discovered in T-lymphocytes and mast cells. STIM1 has been identified as the Ca2+ sensor in the endoplasmic reticulum (ER) that accumulates into punctae close to the plasmamembrane following store-depletion. ORAI1 is a pore subunit of the Ca2+ release-activated Ca2+ channel. It is responsible for store-operated Ca2+ influx, although its role can be compensated partially by ORAI3. All three mammalian ORAI are widely expressed at mRNA level, and all three are plasma membrane proteins. It is also involved in proliferation and cytokine production in T cells. | | | Catalog # | O7044-03B | | Applications | Suitable for use in Western Blot and ELISA. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | ELISA: 1:5000-1:20,000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the intermediate region of human ORAI1. | | Specificity | Recognizes human ORAI1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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