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You are here:Home » Antibodies » Abs to Membrane Proteins » Anti -ORAI1, ID (Transmembrane Protein 142A, TMEM142A, Calcium Release-Activated Calcium Channel Protein 1)

Anti -ORAI1, ID (Transmembrane Protein 142A, TMEM142A, Calcium Release-Activated Calcium
Channel Protein 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Calcium (Ca2+) entry into non-excitable cells is mainly carried by store- operated channels (SOCs), which serve essential functions ranging from regulation of transcription to cell growth. The store-operated current, ICRAC, is the calcium release-activated calcium (CRAC) discovered in T-lymphocytes and mast cells. STIM1 has been identified as the Ca2+ sensor in the endoplasmic reticulum (ER) that accumulates into punctae close to the plasmamembrane following store-depletion. ORAI1 is a pore subunit of the Ca2+ release-activated Ca2+ channel. It is responsible for store-operated Ca2+ influx, although its role can be compensated partially by ORAI3. All three mammalian ORAI are widely expressed at mRNA level, and all three are plasma membrane proteins. It is also involved in proliferation and cytokine production in T cells.
Catalog #O7044-03B
ApplicationsSuitable for use in Western Blot and ELISA. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
ELISA: 1:5000-1:20,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the intermediate region of human ORAI1.
SpecificityRecognizes human ORAI1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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