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Anti -ORAI1 (Transmembrane Protein 142A, TMEM142A, Calcium Release-Activated Calcium Channel Protein 1)
Anti -ORAI1 (Transmembrane Protein 142A, TMEM142A, Calcium Release-Activated Calcium
Channel Protein 1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B |
|
| Orai1 is a Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Defects in Orai1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1) (1). | | | Catalog # | O7044-05 | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 -10,000 | | Optimal dilutions to be determined by the researcher | | Positive Control | Western Blot: Human platelet and Ovary cancer lysates | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Clone No | 11C197 | | Host | Rabbit | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid 50mM tris-glycine, pH7.4, 0.15M NaCl, 40% glycerol, 0.01% sodium azide, 0.05% BSA. | | Purity | Supernatant | | Immunogen | Synthetic peptide corresponding to residues in human Orai1. | | Specificity | Recognizes human Orai 1 at~35/50kD. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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