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You are here:Home » Antibodies » Abs to Membrane Proteins » Anti -ORAI1 (Transmembrane Protein 142A, TMEM142A, Calcium Release-Activated Calcium Channel Protein 1)

Anti -ORAI1 (Transmembrane Protein 142A, TMEM142A, Calcium Release-Activated Calcium
Channel Protein 1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
Orai1 is a Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Defects in Orai1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1) (1).
Catalog #O7044-05
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000 -10,000
Optimal dilutions to be determined by the researcher
Positive ControlWestern Blot: Human platelet and Ovary cancer lysates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No11C197
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid 50mM tris-glycine, pH7.4, 0.15M NaCl, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues in human Orai1.
SpecificityRecognizes human Orai 1 at~35/50kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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