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You are here:Home » Antibodies » Abs to Transmembrane Proteins » Anti -ORAI2 (CAP-Binding Protein Complex-Interacting Protein 2, Transmembrane Protein 142B, Protein orai-2, C7orf19, CBCIP2, TMEM142B)

Anti -ORAI2 (CAP-Binding Protein Complex-Interacting Protein 2, Transmembrane Protein
142B, Protein orai-2, C7orf19, CBCIP2, TMEM142B)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
ORAI2, also known as Transmembrane protein 142B (TMEM142B), is a 28.6kD multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI2 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI2, like ORAI1, functions as a highly selective Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor.
Catalog #O7700-01A
ApplicationsSuitable for use in Immunohistochemistry (frozen) and Western Blot. Other applications not tested.
Recommended DilutionImmunohistochemistry (frozen): 2ug/ml
Western Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenA 15aa peptide from near the carboxy terminus of human ORAI2.
SpecificityRecognizes human ORAI2. No crossreactivity with either ORAI1 or ORAI3. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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