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You are here:Home » Antibodies » Abs to Transmembrane Proteins » Anti -ORAI2, CT (Protein Orai-2, CAP-binding Protein Complex-interacting Protein 2, Transmembrane Protein 142B, C7orf19, CBCIP2, TMEM142B, PP1729)

Anti -ORAI2, CT (Protein Orai-2, CAP-binding Protein Complex-interacting Protein 2,
Transmembrane Protein 142B, C7orf19, CBCIP2, TMEM142B, PP1729)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
ORAI2, also known as Transmembrane protein 142B (TMEM142B), is a 28.6kD multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI2 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI2, like ORAI1, functions as a highly selective Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor.
Catalog #O7700-01B
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 15aa from human ORAI2 at C-terminal (KLH).
SpecificityRecognizes human ORAI2. Species sequence homology: Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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