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You are here:Home » Antibodies » Antibodies-Stem Cell Research » Anti -Osteocrin (OSTN, Musclin)

Anti -Osteocrin (OSTN, Musclin)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
Osteocrin is a recently identified secreted protein expression of which was only detected in bone, peaking just after birth and decreasing markedly with age. A 1280-bp mRNA encodes osteocrin producing a mature protein of 103 amino acids with a molecular mass of 11.4kD. In primary osteoblastic cell cultures osteocrin expression coincided with matrix formation then decreased in very mature cultures. Treatment of cultures with 1,25-dihydroxyvitamin D3 resulted in a rapid dose-dependent down-regulation of osteocrin expression, suggesting direct regulation. Chronic treatment of primary cultures with osteocrin-conditioned media inhibited mineralization and reduced osteocalcin and alkaline phosphatase expression. These results suggest that osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator.
Catalog #O8061-18C
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionsELISA: 1:500
Optimal dilutions to be determined by the researcher.
Amino Acid SequencePhe-Gly-Ile-Pro-Met-Asp-Arg-Ile-Gly-Arg-Asn-Arg-Leu-Ser-Ser-Ser-Arg-Gly
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS. Reconstitute with 200ul sterile dH2O.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa113-130 of mouse Musclin and aa115-132 of rat Musclin.
SpecificityRecognizes mouse Musclin. Species Crossreactivity: rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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