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You are here:Home » Antibodies » Antibodies-Stem Cell Research » Anti -Osteocrin (OSTN, Musclin)

Anti -Osteocrin (OSTN, Musclin)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E
Osteocrin is a recently identified secreted protein expression of which was only detected in bone, peaking just after birth and decreasing markedly with age. A 1280-bp mRNA encodes osteocrin producing a mature protein of 103 amino acids with a molecular mass of 11.4kD. In primary osteoblastic cell cultures osteocrin expression coincided with matrix formation then decreased in very mature cultures. Treatment of cultures with 1,25-dihydroxyvitamin D3 resulted in a rapid dose-dependent down-regulation of osteocrin expression, suggesting direct regulation. Chronic treatment of primary cultures with osteocrin-conditioned media inhibited mineralization and reduced osteocalcin and alkaline phosphatase expression. These results suggest that osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator.
Catalog #O8061-18L
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionImmunohistochemistry (formalin-fixed paraffin): 1:50-100 (ABC, DAB)
Optimal dilutions to be determined by the researcher.
Positive ControlRat/mouse heart tissue
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder. Reconstitute with sterile dH2O.
PurityPurified
ImmunogenSynthetic peptide corresponding to aa83-132 of human Musclin.
SpecificityRecognizes human Musclin. Species crossreactivity: rat and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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