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You are here:Home » Biochemicals » Biochem-Antibiotics » Ostreogrycin A (Mikamycin A, Pristinamycin IIA, Stephylomycin M1, Streptogramin A, Syncothrecin A, Synergistin A1, Virginiamycin M1, Vernamycin A, Antibiotic 14752-2, Antibiotic E129A, Antibiotic PA 114A, Antibiotic 1745Z3A, Antibiotic 547C, Factor M)

Ostreogrycin A (Mikamycin A, Pristinamycin IIA, Stephylomycin M1, Streptogramin A,
Syncothrecin A, Synergistin A1, Virginiamycin M1, Vernamycin A, Antibiotic 14752-2,
Antibiotic E129A, Antibiotic PA 114A, Antibiotic 1745Z3A, Antibiotic 547C, Factor M)

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Specifications

Ostreogrycin A also commonly referred to as virginiamycin M1 or streptogramin A is the major component of the "virginamycin complex". In the 1950s this complex was independently discovered so many times the literature became highly confusing. Ostreogrycin A is a macrocyclic lactone antibiotic that acts syngeristically with the structurally unrelated cyclic depsipeptides more commonly known as the virginiamycins B (ostreogrycin B or streptogramin B) and S to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Ostreogrycin A has proven to be highly active against Gram positive bacteria, particularly methicillin-resistant S. aureus.
Catalog #O8070-50
SolubilitySoluble in DMSO and DMF; partially soluble in methanol and ethanol; poorly soluble in water
Storage and StabilityLyophilized powder may be stored at -20°C. Lyophilized product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number21411-53-0
Molecular FormulaC28H35N3O7
Molecular Weight525.6
SourceStreptomyces sp.
Purity~99% by HPLC
FormSupplied as a white solid
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMikamycin A, Pristinamycin IIA, Stephylomycin M1, Streptogramin A, Syncothrecin A, Synergistin A1, Virginiamycin M1, Vernamycin A, Antibiotic 14752-2, Antibiotic E129A, Antibiotic PA 114A, Antibiotic 1745Z3A, Antibiotic 547C, Factor M


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