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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E B

Glucagon is a member of a multigene family comprising Secretin, Vasoactive Intestinal Peptide (VIP), Gastric Inhibitory Peptide (GIP) and others like Glicentin and Oxyntomodulin (OXM), which differs from glucagon by C-terminal octapeptide.  The glucagon precursor contains at least 3 intervening sequences that divide the protein-coding portion into 4 regions corresponding to the signal peptide and part of the N-terminal peptide, the remainder of the N-terminal peptide and glucagon, glucagon-like peptide-1 (GLP1), and GLP2.
OXM, a 37aa peptide contains the glucagon sequence extended by a C-terminal basic octapeptide, its primary structure is identical in all mammals except in pig and cattle. OXM is released from the gut during digestion, together with glicentin another octapeptide containing molecule. It is considered as a putative physiological regulator of gastric acid secretion, it inhibits histamine.
Catalog #	O8244
Applications	Suitable for use in Western Blot and ELISA. Other applications not tested.
Recommended Dilutons	Western Blot: 1-10ug/ml using ECL.
	ELISA: 0.5-1ug/ml. Control peptide can be used to coat ELISA plates at 1ug/ml.
	Optimal dilutions to be determined by the researcher.
Control Peptide	O8244-01: Oxyntomodulin, Human, Control Peptide (OXM)
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.1% BSA.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide corresponding to 9aa from human Oxyntomodulin (OXM) conjugated to KLH. Species Sequence Homology: rat, mouse and guinea pig, 100%; bovine, porcine and sheep, 89%.
Specificity	Recognizes human OXM.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.