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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -p27Kip1, CT (Cyclin-dependent Kinase Inhibitor 1B, Cyclin-dependent Kinase Inhibitor p27, CDKN1B, KIP1)

Anti -p27Kip1, CT (Cyclin-dependent Kinase Inhibitor 1B, Cyclin-dependent Kinase Inhibitor
p27, CDKN1B, KIP1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
p27Kip1 (cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor p27) is a 27kD cyclin-dependent inhibitor. p27Kip1 is localized in the nucleus and cytoplasm (phospho-specific). This protein functions in G1 arrest and binds and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2. p27Kip1 mediates TGF b-induced G1 arrest and regulates cell motility. This kinase has also been implicated in translational control. Akt phosphorylation causes p27 Kip1 export to cytoplasm; p27 Kip1 has also been shown to be ubiquitinated. p27 Kip1 has been shown to interact with NUP50, Skp2, and PKB/Akt.
Catalog #P1001-11F
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 2ul/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenPeptide corresponding to the C-terminus of human p27.
SpecificityRecognizes human p27Kip1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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