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Abs to Tumor Suppressors
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Anti -p53 (Tumor Protein p53, Tumor Suppressor p53, TP53, TRP53, Cellular Tumor Antigen p53, Phosphoprotein p53, Antigen NY-CO-13, LFS1)
Anti -p53 (Tumor Protein p53, Tumor Suppressor p53, TP53, TRP53, Cellular Tumor Antigen
p53, Phosphoprotein p53, Antigen NY-CO-13, LFS1)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
B IH |
|
| p53 protein is crucial to normal regulation of cell growth and is a suppressor of tumor cell proliferation. The gene encoding for p53 is located on chromosome 17p, a fre- quent site of allelic loss in many tumors. A high propor- tion of breast and colon carcinomas are positive for p53 and this expression correlates with poor prognosis in breast cancer. This antibody recognizes both wild type and mutant forms of p53 protein under denaturing and non-denaturing conditions. | | | Catalog # | P1001-26N4 | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000-1:1500 | | Immunohistochemistry: 1:50-1:100 for 1 hr. at RT | | Optimal dilutions to be determined by the researcher. | | Positive Control | | | Breast and colon carcinomas (nuclear staining pattern) | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | DO-7 | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in 15mM sodium azide. | | Purity | Supernatant | | Immunogen | Recombinant human wild type p53 protein. | | Specificity | Recognizes human p53 Protein. Epitote: aa20-25 of human p53 molecule. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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