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You are here:Home » Antibodies » Abs to Proteasomes » Anti -PA28, alpha (Proteasome Activator 28-alpha subunit)

Anti -PA28, alpha (Proteasome Activator 28-alpha subunit)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. PA700, PA28 and PA200 are three major protein complexes that function as activators of the 20S proteasome. There are three evolutionary conserved subunits of PA28; PA28 (PSME1), PA28 (PSME2) and PA28 (PSME3) (1,2). PA28 and PA28 form a heteroheptameric complex and function by binding to the 20S complex at its opening site(s). The PA28 / complex is present throughout the cell and participates in MHC class I antigen presentation by promoting the generation of antigenic peptide from foreign proteins (2). PA28 exists in the form of a homoheptamer and is mainly located in the nucleus. PA28 complex exerts its function by binding and guiding specific nuclear target proteins to the 20S proteasome for further degradation (3,4).
Catalog #P1700-20
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol and less than 0.02% sodium azide.
PurityPurified by Protein A and immunoaffinity chromatography.
ImmunogenSynthetic peptide (KLH-coupled) corresponding to residues surrounding Lys13 of human PA28 alpha
SpecificityDetects endogenous levels of total PA28 alpha protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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