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You are here:Home » Antibodies » Antibodies-Peptides » Anti -PACAP Related Peptide (Pituitary Adenylate Cyclase Activating Polypeptide Related Peptide, PRP)

Anti -PACAP Related Peptide (Pituitary Adenylate Cyclase Activating Polypeptide Related
Peptide, PRP)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Vasoactive intestinal peptide (VIP) is a 28-aminoacid peptide (human, chr 6q26-q27). Expressed and secreted by neurons innervating primary and secondary immune organs such as lymph nodes with a Mol.wt of 20kD. VIP is a potent neurotrophic factor causes vasodilation, lowers arterial blood pressure, and relaxes the smooth muscle of trachea, stomach and gall bladder. VIP also modulates several T-lymphocyte activities including motility, cytokine production, proliferation and apoptosis, VIP exerts its biological activity by binding to two closely related class II G-protein-coupled receptors VPAC-1 and VPAC-2 beside this VIP has its own receptors VIPR1&2 (Vasoactive Intestinal Polypeptide Receptor 1&2) and VIPRRP (VIP receptor-gene repressor protein). VIP shows similarities to glucagon, secretin and gastric inhibitory peptide (GIP) as such it has been considered a member of the glucagon-secretin family. The VIP is 100% conserved in mouse, rat and human. VIP is considered to be a viable candidate for the development of treatments for rheumatoid arthritis, since treatment with VIP significantly reduced incidence of severity of arthritis, the therapeutic effect of VIP was associated with downregulation of both inflammatory and autoimmune components of the disease. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a bioactive peptide (human 176aa, 175 each in mouse and rat) that was originally isolated from ovine hypothalamus on the basis of its ability to stimulate adenylate cyclase and functions as a neurotransmitter and neuromodulator The N-terminal amino acid sequence of PACAP shows 68% identity with VIP and more limited similarity with growth hormone-releasing hormone.
PRP (PACAP Related Peptide), a 29 amino-acid region of the PACAP precursor protein, has been synthesized in quantities sufficient for biological and structural studies. PRP has a distinct biological activity on the gallbladder that is similar to PACAP, but opposite to that of VIP and its related peptide, PHM.
Catalog #P1775-01L
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml. See P1775-01M.
Western Blot: 1-10ug/ml using ECL technique.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
Immunogen11aa peptide from human PRP. Location
SpecificityRecognizes human PACAP Related Peptide.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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