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Anti -PAG (Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1, Transmembrane Adapter Protein PAG, Csk-Binding Protein, Transmembrane Phosphoprotein Cbp, PAG1, CBP)
Anti -PAG (Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1,
Transmembrane Adapter Protein PAG, Csk-Binding Protein, Transmembrane Phosphoprotein Cbp,
PAG1, CBP)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B |
|
| P1951-10 specifically recognizes the transmembrane adaptor protein known as Protein Associated with Glycosphingolipid-enriched microdomains (PAG), an epitope (aa235-280) located in the cytoplasmic domain of csk-binding protein (Cbp), which localizes in membrane lipid rafts. | | | Catalog # | P1951-10 | | The engagement of immunoreceptors with natural ligands or antibodies is the initiating factor in a long line of events down a cytosolic signaling cascade. The transmission of signals along the various pathways within this cascade requires the phosphorylation of various substrates, by members of the src and syk families of protein tyrosine kinases (PTKs). | | Evidence has shown that by binding to the SH2 domain of the PTK csk, a major negative regulator of src-family kinases, PAG acts not only acts as a ‘co-factor’ for relocating csk to substrate rich microdomains, but also increases the affinity of csk for src-family kinases, through the formation of PAG-csk complexes. | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 10F262 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Recombinant intracellular fragment (aa97-432) of human Cbp/PAG | | Specificity | Recognizes human PAG. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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